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Related Experiment Video

Updated: May 7, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Tamara Pringsheim¹, Constadina Panagiotopoulos, Jana Davidson

¹Département de neurosciences cliniques et de pédiatrie, université de Calgary (Alberta);

Paediatrics & Child Health

|October 2, 2013

Summary

This summary is machine-generated.

Second-generation antipsychotics (SGAs) are increasingly used in children, but carry risks of metabolic and neurological side effects. This study provides evidence-based monitoring guidelines to improve care for pediatric patients on SGAs.

Keywords:

Antipsychotics Children and adolescents Drug safety Extrapyramidal symptoms Metabolic syndrome

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Area of Science:

Child and Adolescent Psychiatry
Pharmacology
Clinical Pediatrics

Context:

Rising use of second-generation antipsychotics (SGAs) in Canadian pediatric mental health populations.
SGAs carry significant risks of metabolic and neurological complications with chronic use in children.
Need for evidence-based monitoring strategies for pediatric SGA use.

Purpose:

To systematically review evidence on metabolic and neurological side effects of SGAs in children.
To develop evidence-based recommendations for monitoring SGA-associated adverse events.
To provide guidance for clinicians managing pediatric patients on SGAs.

Summary:

Systematic review of controlled trials identified specific metabolic and neurological risks associated with various SGAs in pediatric populations.
Olanzapine, clozapine, and quetiapine pose the highest risk for metabolic side effects (weight gain, dyslipidemia).
Risperidone, olanzapine, and aripiprazole are associated with the greatest risk of neurological side effects.

Impact:

Guidelines offer specific recommendations for physical examinations and laboratory tests for monitoring SGA safety.
Implementation of these guidelines can enhance the quality of care for children receiving SGAs.
Facilitates informed clinical decision-making regarding the benefits and risks of pediatric SGA treatment.