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Ewing sarcoma protein: a key player in human cancer
1Department of Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy ; Laboratory of Cellular and Molecular Neurobiology, Fondazione Santa Lucia IRCSS, 00143 Rome, Italy.
International Journal of Cell Biology
|October 2, 2013
Summary
The Ewing sarcoma protein (EWS) regulates gene expression and DNA damage response, crucial for genome stability and cell-cycle progression. Its roles extend beyond cancer translocations, impacting cellular processes and potentially offering therapeutic targets.
Area of Science:
- Molecular Biology
- Cancer Biology
- Genetics
Background:
- Ewing sarcoma protein (EWS) is implicated in sarcomas via translocations like EWS-FLI1.
- The chimeric EWS-FLI1 protein lacks EWS RNA-binding domains, but EWS's independent role in cancer is unclear.
- Recent studies link EWS to DNA damage response (DDR), vital for genome stability.
Purpose of the Study:
- To review EWS structural features and its roles in gene expression.
- To examine EWS involvement in DDR and cancer-related genes for therapeutic implications.
- To discuss EWS in neuromuscular disorders and its contribution to genome stability.
Main Methods:
- Literature review of EWS functions in gene expression.
- Analysis of EWS roles in DNA damage response pathways.
- Synthesis of information on EWS involvement in cancer and neuromuscular disorders.
Main Results:
- EWS coordinates pre-mRNA synthesis and processing, regulating gene expression.
- EWS plays a critical role in DDR, maintaining genome stability.
- EWS influences cancer-related genes and has implications for cancer therapy.
Conclusions:
- EWS broadly bridges cellular processes, contributing to genome stability and cell-cycle progression.
- Understanding EWS functions offers insights into cancer development and potential therapeutic strategies.
- EWS is a key regulator in higher eukaryotic cells, impacting gene expression and DNA repair.
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