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Hapten-specific unresponsiveness in mice. III. Study of the B-cell functions of tolerant mice

R Huchet, D Grandjon

    Scandinavian Journal of Immunology
    |April 1, 1985
    PubMed

    The features of B-cell tolerance induced in mice with the chemically reactive hapten 2,4,6-trinitrobenzenesulphonic acid were investigated after various antigenic challenges. A complete abolition of the IgG response was observed after challenge with trinitrophenol (TNP)-coupled haemocyanin (TNP-KLH) associated or not with Escherichia coli lipopolysaccharide. Carrier immunization with KLH (3 micrograms) followed by challenge with TNP-KLH led to a normal IgG anti-TNP response. However, tolerant mice given 3 micrograms TNP-KLH (instead of KLH) and a repeat injection of TNP-KLH exhibited a depressed IgG anti-TNP response. These results are discussed within the framework of tolerance induction in adult mature B cells.

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