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Multidisciplinary collaborative therapy for 30 children with orbital rhabdomyosarcoma
Xin Ge1, Dong-Sheng Huang, Ji-Tong Shi
1Key Laboratory of Beijing Ophthalmology and Visual Science, Beijing Tongren Eye Center, Affiliated Beijing Tongren Hospital of Capital Medical University, Beijing, China
Asian Pacific Journal of Cancer Prevention : APJCP
|October 3, 2013
Summary
A multidisciplinary approach to treating orbital rhabdomyosarcoma (RMS) in children demonstrates effectiveness. This comprehensive strategy improved tumor remission rates and survival outcomes in pediatric patients.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Radiation Oncology
Background:
- Orbital rhabdomyosarcoma (RMS) is a rare and aggressive malignancy affecting children.
- Effective treatment strategies are crucial for improving patient outcomes and survival rates.
Purpose of the Study:
- To evaluate the clinical experience and outcomes of treating pediatric orbital rhabdomyosarcoma (RMS).
- To propose a comprehensive, multidisciplinary treatment model for orbital RMS in children.
Main Methods:
- Retrospective analysis of 30 pediatric patients with primary orbital RMS (2004-2012).
- Patients received comprehensive treatment including surgery, chemotherapy, radiotherapy, 125I radioactive particle implantation, and stem-cell transplantation.
- Staging followed International Rhabdomyosarcoma Organization Standards (Stages II-IV).
Main Results:
- Median follow-up was 47.2 months; 7 deaths occurred.
- Estimated survival rates: 86.1% at 2 years, 77% at 3 years, and 70.6% at 5 years.
- The multidisciplinary approach showed promising survival rates.
Conclusions:
- A multidisciplinary collaborative model is a safe and effective treatment for pediatric orbital RMS.
- This comprehensive approach significantly improves tumor remission rates and patient survival.
- The model offers clinical significance in managing this challenging pediatric cancer.
