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Peripheral vascular dysfunction in migraine: a review.

Simona Sacco¹, Patrizia Ripa, Davide Grassi

¹Department of Neurology and Regional Headache Center, University of L'Aquila, Piazzale Salvatore Tommasi 1, L'Aquila, 67100, Italy. simona.sacco@yahoo.com.

The Journal of Headache and Pain

|October 3, 2013

Summary

This summary is machine-generated.

Migraine patients show altered arterial function, a potential indicator of vascular health. Further research is needed to confirm if this explains their increased risk of vascular disease.

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Published on: June 2, 2014

Area of Science:

Vascular Medicine
Neurology

Background:

Migraine is linked to an increased risk of vascular disease.
Endothelial and arterial dysfunction are proposed mechanisms, but evidence is inconsistent.

Purpose of the Study:

To systematically review and summarize evidence on peripheral vascular dysfunction in migraineurs.

Main Methods:

Systematic literature search across multiple databases (BIOSIS, Cochrane, Embase, Google Scholar, Web of Science, Medline) up to April 2013.
Inclusion of studies evaluating endothelial and arterial function in migraineurs.

Main Results:

Evidence on endothelial function in migraineurs is controversial, with studies showing dysfunction, no difference, or even enhanced function.
Reports on arterial function are more consistent, suggesting altered functional properties of large arteries in migraineurs.

Conclusions:

Peripheral arterial function may serve as a non-invasive marker for vascular health in migraine patients.
More research is required to establish if altered arterial function contributes to the elevated vascular disease risk in migraine.