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Updated: May 7, 2026

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
Published on: April 23, 2017
Glycosyl-Nucleolipids as new bioinspired amphiphiles
Laurent Latxague1, Amit Patwa, Eric Amigues
1INSERM U869, Bordeaux, F-33076, France. philippe.barthelemy@inserm.fr.
Abstract:
Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lower glim) compared to the first generation of GNFs.
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