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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Q-bodies monitor the quinary state of the protein fold
Daniela Martino Roth1, William E Balch
1The Scripps Research Institute, Department of Cell and Molecular Biology, 10555 North Torrey Pines Road, La Jolla, California 92037, USA.
Abstract:
Cytoplasmic compartments containing misfolded proteins targeted for degradation, named Q-bodies, have been identified. Q-body formation is a dynamic process that actively manages the metastable state of the protein fold through small heat shock proteins and the Hsp70-Hsp90-Hsp110 proteostasis system to promote cellular fitness under both physiological and stress conditions.
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