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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: May 7, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Network-based approaches for anticancer therapy (Review).

Hyunjeong Seo1, Wanyeon Kim, Jihyung Lee

  • 1Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.

International Journal of Oncology
|October 3, 2013
PubMed
Summary
This summary is machine-generated.

Cancer cells develop resistance to therapies by altering signaling networks. Targeting key molecular hubs within these networks offers a promising strategy to improve cancer treatment efficacy and reduce side effects.

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

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Last Updated: May 7, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Area of Science:

  • Systems Biology
  • Cancer Biology
  • Network Medicine

Background:

  • Cancer involves complex alterations in multiple signaling networks, often exhibiting scale-free properties with critical 'hub' molecules.
  • Hubs are vital network components and potential biomarkers; targeting them could enhance cancer treatment effectiveness.
  • Current therapies like chemotherapy and radiotherapy can paradoxically induce cancer cell resistance by activating alternative pathways.

Purpose of the Study:

  • To review current research on cancer-associated complex networks.
  • To examine how these networks modulate in response to cancer therapy.
  • To explore network-based therapeutic strategies for improving cancer treatment outcomes.

Main Methods:

  • Review of existing literature on cancer signaling networks and therapeutic responses.
  • Analysis of network properties, including scale-free characteristics and hub identification.
  • Discussion of network modulation mechanisms and their role in chemoresistance and radioresistance.

Main Results:

  • Cancer networks are dynamic and can rewire in response to therapy, leading to resistance.
  • Hub molecules play a crucial role in network flexibility and therapy-induced adaptations.
  • Identifying key molecules controlling network modulation is essential for overcoming treatment failure.

Conclusions:

  • Network-based therapies targeting network flexibility and hub molecules show promise for improving cancer treatment.
  • Understanding and manipulating cancer network dynamics can minimize side effects and enhance therapeutic efficacy.
  • Further research into network modulation is critical for developing more effective cancer treatments.