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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

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Related Experiment Video

Updated: May 7, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
07:49

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

Tissue resident stem cells: till death do us part.

Hadas Raveh-Amit1, Sara Berzsenyi, Virag Vas

  • 1Biotalentum Ltd, Godollo, 2100, Hungary.

Biogerontology
|October 3, 2013
PubMed
Summary

Aging impairs tissue regeneration and adult stem cell function, with distinct mechanisms affecting different cell types. Understanding these age-related stem cell changes is crucial for developing effective therapies for age-associated diseases.

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Last Updated: May 7, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
07:49

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Published on: July 5, 2010

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
07:14

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Aging leads to decreased regenerative capacity in tissues and organs.
  • Adult stem cell function declines with age, contributing to various pathologies.
  • Age-related stem cell alterations are tissue-specific, necessitating tailored research approaches.

Purpose of the Study:

  • To review mechanisms of age-related stem cell dysfunction and reduced tissue regeneration.
  • To explore tissue-specific differences in aging stem cells.
  • To discuss the link between stem cell aging and human diseases, including therapeutic perspectives.

Main Methods:

  • Comprehensive literature review focusing on age-related stem cell research.
  • Analysis of studies on hematopoietic, neural, mesenchymal, and skeletal stem cells.
  • Examination of the connection between stem cell aging and disease pathogenesis.

Main Results:

  • Distinct mechanisms underlie age-related dysfunction in different stem cell types.
  • Aging impacts regenerative capacity across various tissues.
  • Specific age-related stem cell changes are linked to distinct pathophysiological outcomes.

Conclusions:

  • Tissue-specific mechanisms drive age-related stem cell dysfunction and impaired regeneration.
  • Understanding these differences is key to addressing age-related diseases.
  • Future stem cell therapies must consider the unique aging profiles of different stem cell populations.