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Updated: Aug 18, 2026

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue
Published on: October 1, 2008
Brain neurotransmitter abnormalities in neuronal intranuclear inclusion body disorder
Abstract:
Biochemical markers for the major neurotransmitter systems were measured in the brain of a patient who died with neuronal intranuclear inclusion disease. A severe nigrostriatal dopamine deficiency constitutes the basis for the parkinsonian features in the patient. A marked loss of brain norepinephrine and serotonin was found in the basal ganglia and hypothalamus. Brain amino acid (gamma-aminobutyric acid and glutamate) and cholinergic (choline acetyltransferase activity) systems were either normal or less severely affected.
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