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Nucleotide excision repair in eukaryotes

Orlando D Schärer1

  • 1Department of Pharmacological Sciences and Department of Chemistry, Stony Brook University, Stony Brook, New York 11974-3400.

Cold Spring Harbor Perspectives in Biology
|October 3, 2013
PubMed

Insights

Nucleotide excision repair (NER) removes bulky DNA damage in mammals. Recent studies reveal NER

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Nucleotide excision repair (NER) is crucial for removing DNA lesions from UV radiation, mutagens, and chemotherapy.
  • Defects in NER are linked to xeroderma pigmentosum, a disorder causing extreme sun sensitivity and high skin cancer risk.

Purpose of the Study:

  • To provide a detailed overview of the NER pathway.
  • To highlight recent advancements in understanding NER mechanisms, chromatin interactions, and connections to other cellular processes.

Main Methods:

  • Biochemical studies
  • Structural analyses
  • Cell biological experiments
  • Genetic studies

Main Results:

  • Elucidation of the core NER reaction and involved factors.
  • Detailed insights into NER's operation within chromatin.
  • Understanding NER's integration with DNA damage signaling and transcription.

Conclusions:

  • Recent research has significantly advanced the understanding of the NER pathway.
  • NER is a complex process intricately linked with chromatin regulation and cellular signaling.

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