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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
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Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

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Updated: May 7, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Hepcidin-minireview.

Subha Palaneeswari M1, M Ganesh, T Karthikeyan

  • 1Assistant Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital (Bharath University) , Chrompet, Chennai-600 044, India .

Journal of Clinical and Diagnostic Research : JCDR
|October 3, 2013
PubMed
Summary
This summary is machine-generated.

Hepcidin is a key hormone regulating iron levels in the body. Understanding hepcidin

Keywords:
FerroportinHepcidinHepcidin disorders

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Last Updated: May 7, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

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Published on: August 30, 2018

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Published on: May 10, 2022

Area of Science:

  • Biochemistry
  • Physiology
  • Medicine

Background:

  • Iron homeostasis is crucial for health, involving complex transport and storage mechanisms.
  • Hepcidin, a peptide hormone, plays a central role in systemic iron regulation.
  • Disruptions in iron metabolism are linked to various human diseases.

Purpose of the Study:

  • To review the structure, kinetics, and function of hepcidin.
  • To explore the correlation between hepcidin and iron metabolism disorders.
  • To discuss the therapeutic and diagnostic potential of hepcidin modulation and measurement.

Main Methods:

  • Literature review of studies on hepcidin and iron metabolism.
  • Analysis of hepcidin's role in iron transport and storage.
  • Evaluation of clinical data related to hepcidin concentrations in disease.

Main Results:

  • Hepcidin acts as a master regulator of iron absorption and recycling.
  • Altered hepcidin levels are associated with diverse iron-related disorders.
  • Hepcidin measurements show diagnostic utility in clinical practice.

Conclusions:

  • Hepcidin is a critical determinant of systemic iron balance.
  • Modulating hepcidin offers therapeutic strategies for iron disorders.
  • Hepcidin assessment is valuable for diagnosing and managing iron-related conditions.