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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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[Vasomotor endothelial dysfunction in young men with grade 1 arterial hypertension]

A R Zairova1, E V Oshchepkova, A N Rogoza

  • 1Institute of Cardiology, Russian Cardiology Scientific and Production Center, Tretiya Cherepkovskaya str.,15a, 121552 Moscow, Russia.

Kardiologiia
|October 4, 2013
PubMed

Insights

Young men with grade 1 arterial hypertension have significantly impaired endothelial function. Key risk factors include family history, smoking, high cholesterol, and elevated red blood cell distribution width (RDW).

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Hypertension Research

Background:

  • Endothelial dysfunction is an early sign of cardiovascular disease.
  • Grade 1 arterial hypertension (G1AH) affects young men, increasing long-term cardiovascular risk.
  • Understanding endothelial function in G1AH is crucial for early intervention.

Purpose of the Study:

  • To investigate vasomotor endothelial function in young men with G1AH.
  • To identify risk factors associated with endothelial dysfunction in this population.

Main Methods:

  • Ultrasound assessment of flow-mediated vasodilatation (FMD) of the brachial artery.
  • Comparison between 76 men with G1AH and 30 healthy controls (aged 20-40 years).
  • Analysis of risk factors including smoking, cholesterol levels, family history, and red blood cell distribution width (RDW).

Main Results:

  • Endothelial dysfunction (FMD<6%) was significantly more prevalent in men with G1AH (51%) compared to healthy controls (13%).
  • In G1AH, risk factors for endothelial dysfunction included family history of early cardiovascular disease, smoking, and elevated low-density cholesterol.
  • The probability of endothelial dysfunction increased substantially with the number of risk factors present (11% with none, 83% with three).
  • Elevated RDW (>14.8%) was strongly associated with endothelial dysfunction, increasing its probability fivefold in men with G1AH.

Conclusions:

  • Young men with G1AH exhibit significant endothelial dysfunction.
  • Identifying and managing risk factors like smoking, high cholesterol, family history, and elevated RDW is critical for preventing cardiovascular events in G1AH.
  • RDW may serve as a novel biomarker for endothelial dysfunction in young hypertensive men.

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