[Clinical course and outcomes of myocardial infarction in women]

We selected all case histories of patients living in the area served by the Syktyvkar policlinic #3 and treated in Republican Cardiological Dispensary in 2003-2009 with diagnosis of myocardial infarction (MI). Data on survival of patients after MI (mean duration of follow-up 4.6 years) was derived from information on date and cause of death of patients obtained from statistical office of the policlinic. Overall we analyzed data on 778 patients (46.3% women, mean age 63.7 years). For detection of independent factors related to lethal outcome we used binary logistic regression, for assessment of survival we used Kaplan-Meier method and Cox regression model of proportional hazards. From positions of gender differences we assessed pharmacoepidemiology of MI, efficacy of thrombolytic therapy, determined factors of hospital and long term mortality. No increase of risk of hospital or long term mortality associated with female sex was revealed by multifactorial analysis. Greatest prognostic significance in relation to unfavorable outcome irrespective of patients sex was established for the following factors: age, severity of MI course, severity of renal dysfunction. In acute period of MI in addition to these factors we revealed unfavorable influence of hyperglycemia and protective role of preceding hypertensive disease.