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Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes
Published on: February 9, 2009
A comprehensive map of the influenza A virus replication cycle
Yukiko Matsuoka1, Hiromi Matsumae, Manami Katoh
1JST ERATO Kawaoka infection-induced host responses project, Minato-ku, Tokyo 108-8639, Japan. kawaoka@ims.u-tokyo.ac.jp.
BMC Systems Biology
|October 4, 2013
Summary
This study presents FluMap, a comprehensive map of the influenza A virus life cycle, detailing molecular interactions and host responses. FluMap aids in identifying potential drug targets for influenza infection.
Area of Science:
- Virology
- Systems Biology
- Immunology
Background:
- Influenza virus causes annual epidemics with significant global health and economic impact.
- Understanding influenza virus-host interactions is crucial for developing effective countermeasures.
- Existing knowledge on influenza mechanisms and host responses is fragmented.
Purpose of the Study:
- To create a comprehensive pathway map of the influenza A virus (IAV) life cycle.
- To integrate existing knowledge and facilitate the identification of host response mechanisms and drug targets.
- To provide a platform for community discussion and analysis of influenza-host interactions.
Main Methods:
- Manual literature curation and integration with public pathway databases.
- Construction of the FluMap using CellDesigner software in SBML format.
- Visualization of the map using SBGN diagrams and availability as a web service.
Main Results:
- The FluMap comprises 960 factors and 456 reactions, annotated with extensive literature references.
- Includes detailed molecular interactions and isolate/strain-specific data.
- Demonstrates computational network analyses for target identification.
Conclusions:
- FluMap serves as a knowledge base and analytical platform for IAV-host interactions.
- Continuous updates via web tools ensure an accurate representation of the host-virus network.
- The FluMap is publicly accessible at http://www.influenza-x.org/flumap/.
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