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Updated: Aug 10, 2026
02:46
A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
Published on: January 20, 2023
Chemotherapy-induced eosinophilic pneumonia. Relation to bleomycin
Chest
|July 1, 1985
Summary
Bleomycin chemotherapy can cause eosinophilic pneumonia, a rare hypersensitivity reaction. This differs from the typical diffuse alveolar damage often seen with this treatment.
Area of Science:
- Pulmonology
- Oncology
- Pharmacology
Background:
- Bleomycin is an antineoplastic agent used in cancer treatment.
- Pulmonary toxicity is a known side effect of bleomycin therapy.
- Diffuse alveolar damage is the most common histopathological finding in bleomycin-induced lung injury.
Purpose of the Study:
- To report three cases of eosinophilic pneumonia associated with bleomycin chemotherapy.
- To differentiate this presentation from typical bleomycin-induced lung injury.
Main Methods:
- Case series review.
- Clinical and pathological analysis of three patients treated with bleomycin.
Main Results:
- Three patients developed eosinophilic pneumonia during bleomycin treatment.
- Histopathological findings were consistent with eosinophilic pneumonia, not diffuse alveolar damage.
- Symptoms included cough and dyspnea.
Conclusions:
- Eosinophilic pneumonia is a potential, albeit uncommon, manifestation of bleomycin-induced lung injury.
- This presentation suggests a hypersensitivity reaction rather than direct drug toxicity.
- Clinicians should consider eosinophilic pneumonia in patients on bleomycin presenting with respiratory symptoms.
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