Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is Allosensitization Detrimental to Pig Organ Xenotransplantation, and Is Xenosensitization Detrimental to Subsequent Organ Allotransplantation? A Debate Organized by the International Xenotransplantation Association (IXA).

Xenotransplantation·2024
Same author

Characterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation-A narrative review.

American journal of hematology·2024
Same author

The Time Has Come: The Case for Initiating Pilot Clinical Trials of Pig Kidney Xenotransplantation.

Annals of surgery·2024
Same author

Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2024
Same author

The importance of public engagement in clinical xenotransplantation.

Health care science·2024
Same author

Novel factors potentially initiating acute antibody-mediated rejection in pig kidney xenografts despite an efficient immunosuppressive regimen.

Xenotransplantation·2024
Same journal

Beyond galactose deficiency: redefining pathogenic IgA in IgA nephropathy.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

Kidney international·2026
Same journal

KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

Kidney international·2026
Same journal

Crystal-storing histiocytosis causing severe acute kidney injury.

Kidney international·2026
Same journal

Peritoneal dialysis in a patient with extensive burn scarring.

Kidney international·2026
Same journal

COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

Kidney international·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Kidney xenotransplantation.

Peter J Cowan1, David K C Cooper2, Anthony J F d'Apice1

  • 11] Immunology Research Centre, St Vincent's Hospital, Melbourne, Victoria, Australia [2] Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

Kidney International
|October 4, 2013
PubMed
Summary
This summary is machine-generated.

Pig kidney transplants could solve donor shortages but face immune rejection. Genetic modification of donor pigs shows promise in overcoming these challenges and improving xenograft survival.

More Related Videos

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

Related Experiment Videos

Last Updated: May 7, 2026

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

Area of Science:

  • Transplantation immunology
  • Genetics
  • Nephrology

Background:

  • Pig kidney (porcine renal) xenotransplantation offers a solution to the chronic shortage of human donor kidneys.
  • However, significant obstacles remain, primarily complex immune rejection processes.

Purpose of the Study:

  • This review focuses on the pathophysiology of porcine renal xenograft rejection.
  • It also highlights genetic, pharmacological, and technical advancements aimed at prolonging xenograft survival.

Main Methods:

  • The review synthesizes preclinical data on porcine renal xenograft rejection mechanisms.
  • It examines the role of genetic modification in addressing cross-species incompatibilities.

Main Results:

  • Porcine renal xenografts face rejection due to antibodies, innate immune cells, coagulation issues, and T cell responses.
  • Cross-species molecular defects exacerbate xenograft susceptibility to inflammatory stimuli.

Conclusions:

  • Genetic modification of donor pigs is a key strategy to overcome xenograft rejection.
  • Significant progress has been made in improving the survival of porcine renal xenografts.