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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...

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Updated: May 7, 2026

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
05:46

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue

Published on: June 9, 2020

Lineage-tracing methods and the kidney.

Benjamin D Humphreys1, Derek P DiRocco2

  • 11] Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA [2] Harvard Medical School, Boston, Massachusetts, USA [3] Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.

Kidney International
|October 4, 2013
PubMed
Summary
This summary is machine-generated.

Genetic lineage tracing in mice clarifies kidney cell development and disease. This powerful technique tracks cell progeny, advancing our understanding of kidney biology and regeneration.

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Last Updated: May 7, 2026

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
05:46

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Published on: June 9, 2020

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

Area of Science:

  • Nephrology
  • Developmental Biology
  • Genetics

Background:

  • The kidney comprises over 30 cell types, making lineage relationships complex.
  • Understanding kidney development (nephrogenesis) and mature kidney processes (injury, regeneration, aging) is crucial for disease insights.

Purpose of the Study:

  • To review genetic lineage-tracing methods for studying kidney biology.
  • To highlight the impact of these methods on understanding kidney development and disease.

Main Methods:

  • Focus on genetic lineage tracing techniques, including inducible recombinases, multicolor reporters, and mosaic analysis.
  • Utilizes the mouse model system for detailed cellular tracking.

Main Results:

  • Lineage tracing enables unambiguous tracking of cell progeny.
  • Advances in techniques have significantly improved the ability to decipher cellular hierarchies.

Conclusions:

  • Genetic lineage tracing is a powerful tool for understanding kidney cell hierarchies in development and disease.
  • These methods offer significant prospects for future kidney research and therapeutic development.