Real-time atlas-based stereotactic neuronavigation
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Updated: May 7, 2026
A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
Published on: July 16, 2020
Mark Vabulas1, Vinodh A Kumar, Jackson D Hamilton
1*Anatom-e Information Systems, Ltd., Houston, Texas; ‡Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas; §Brainlab Inc, Westchester, Illinois; ‖Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Background:
Surgery for tumors in eloquent brain faces immense challenges when attempting to maximize resection and avoid neurological deficits.
Objective:
In order to give the surgeon real-time atlas-based anatomic information linked to the patient's anatomy, we developed a software-based interface between deformable anatomic templates (DATs) and an intraoperative navigation system.
Methods:
Magnetic resonance imaging (MRI), diffusion tensor imaging, and/or functional MRI were performed on 3 patients preoperatively for the purposes of tumor resection by the use of neuronavigation. The DAT was registered to the patients' navigation coordinate system and utilized coordinates from the navigation system during surgery. This provided the surgeon with a list of proximal anatomic and functional structures and a real-time image of the atlas at that location fused to the patient's MRI. The clinical feasibility of this approach was evaluated during the resection of 3 eloquent tumors (right postcentral gyrus, left inferior frontal gyrus, and left occipital cuneus gyrus).
Results:
Tumor resection was performed successfully in all 3 patients. With the use of the coordinates from the navigation system, anatomic and functional structures and their distances were visualized interactively during tumor resection by using the DAT.
Conclusion:
This is a proof of concept that an interactive atlas-based navigation can provide detailed anatomic and functional information that supplements MRI, diffusion tensor imaging, and functional MRI. The atlas-based navigation generated distances to important anatomic structures from the navigation probe tip. It can be used to guide direct electrical stimulation and highlight areas to avoid during tumor resection.
Abbreviations:
DAT, deformable anatomic templateDES, direct electrical stimulationDTI, diffusion tensor imagingfMRI, functional magnetic resonance imaging.
