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MicroRNAs in kidney fibrosis and diabetic nephropathy: roles on EMT and EndMT

Swayam Prakash Srivastava1, Daisuke Koya, Keizo Kanasaki

  • 1Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan.

Biomed Research International
|October 4, 2013
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are key in kidney fibrosis. Targeting these small RNAs offers a promising therapeutic strategy for kidney diseases like diabetic nephropathy.

Area of Science:

  • Biomedical research
  • Molecular biology
  • Nephrology

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression in biological and pathological processes.
  • Kidney fibrosis involves excessive extracellular matrix deposition due to ECM metabolism imbalance.
  • miRNAs are implicated in fibrotic processes across multiple organs, including the kidney.

Purpose of the Study:

  • To review recent advances on the role of miRNAs in kidney diseases, particularly diabetic nephropathy.
  • To focus on the epithelial-mesenchymal transition (EMT) and endothelial-mesenchymal transition (EndMT) programs in kidney fibrosis development.
  • To highlight miRNAs as potential therapeutic targets for kidney fibrosis.

Main Methods:

  • Literature review of recent advances in miRNA research related to kidney fibrosis.
  • Focus on studies investigating the role of miRNAs in EMT and EndMT pathways.
  • Analysis of current understanding of miRNA involvement in diabetic nephropathy and kidney fibrosis.

Main Results:

  • miRNAs play significant roles in regulating gene expression relevant to kidney fibrosis.
  • EMT and EndMT programs are critical in the pathogenesis of kidney fibrosis.
  • Numerous extracellular and intracellular molecules controlling EMT and EndMT have been identified.

Conclusions:

  • miRNAs are crucial regulators in kidney fibrosis, particularly in diabetic nephropathy.
  • Targeting specific miRNAs involved in EMT and EndMT presents a novel therapeutic avenue.
  • Further research into miRNA mechanisms can lead to effective treatments for kidney fibrosis.

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