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Related Experiment Videos

Tear histamine during allergic conjunctivitis challenge.

O Kari, O P Salo, L Halmepuro

    Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
    |January 1, 1985
    PubMed
    Summary
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    Allergen challenges in allergic conjunctivitis patients increased tear histamine in most, but not all, individuals. This histamine release occurred in both eyes, suggesting complex mechanisms beyond the direct allergen exposure.

    Area of Science:

    • Ophthalmology
    • Allergology
    • Immunology

    Background:

    • Allergic conjunctivitis is a common ocular condition characterized by inflammation of the conjunctiva.
    • Histamine is a key mediator in allergic reactions, contributing to symptoms like itching and redness.
    • Understanding histamine release patterns is crucial for managing allergic conjunctivitis.

    Purpose of the Study:

    • To investigate tear histamine levels in patients with allergic conjunctivitis during allergen challenge.
    • To determine the correlation between clinical reactions and histamine release in the eyes.

    Main Methods:

    • Tear samples were collected from 14 patients with allergic conjunctivitis.
    • A standardized allergen challenge test was performed at a time when patients were symptom-free.

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  • Tear histamine concentrations were measured before and after allergen exposure.

    • Main Results:

    • An increase in tear histamine was observed in two-thirds of patients following allergen challenge.
    • Clinical reactions were present in all patients, irrespective of measurable histamine increase.
    • Histamine levels rose in both the challenged and contralateral non-challenged eyes, with similar magnitude.

    Conclusions:

    • Allergen challenge triggers histamine release in allergic conjunctivitis, but not universally detected in tears.
    • Bilateral histamine increase suggests systemic or neural influences on lacrimal gland function.
    • Further research is needed to elucidate the sympathetic mechanisms involved in contralateral eye responses.