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Updated: May 7, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Zinc-mediated highly α-regioselective 1,4-addition of chalcones with prenyl bromide in THF
Li-Ming Zhao1, Shu-Qing Zhang, Fei Dou
1School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou 221116, Jiangsu, China.
Abstract:
α-Regioselective addition to chalcones was realized by use of in situ generated prenylzinc reagents from zinc and prenyl bromide in the presence of SnCl4 in a 1,4-addition fashion. The approach uses the reagent combination of prenyl bromide, zinc, and SnCl4 in THF, all of which are inexpensive, readily available, and easily removable after the reaction.
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