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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

Controversies in preventive therapy for children contacts of multidrug-resistant tuberculosis

Elena Chiappini, Sara Sollai, Francesca Bonsignori

    Journal of Chemotherapy (Florence, Italy)
    |October 5, 2013
    PubMed

    Insights

    Preventive therapy for drug-resistant tuberculosis (DR-TB) contacts may benefit high-risk children, but optimal regimens and use in other groups remain unclear. Further research is needed for managing paediatric DR-TB contacts.

    Area of Science:

    • Public Health
    • Infectious Diseases
    • Pediatrics

    Background:

    • Drug-resistant tuberculosis (DR-TB) presents a growing global health challenge.
    • Management strategies for child contacts of DR-TB cases lack international consensus.

    Purpose of the Study:

    • To assess the effectiveness of post-exposure chemoprophylaxis in paediatric DR-TB contacts.
    • To synthesize findings from existing literature and international guidelines.

    Main Methods:

    • A comprehensive literature search was performed across major databases (Cochrane Library, PubMed, EMBASE) up to September 2012.
    • Included studies comprised population studies, international guidelines, and narrative reviews.

    Main Results:

    • Eighteen relevant articles were identified and analyzed.
    • Preventive therapy is generally agreed upon for high-risk groups like immunocompromised children and those under 5 years old.

    Conclusions:

    • While preventive therapy is supported for specific high-risk paediatric populations, consensus is lacking for older or immunocompetent children.
    • Further research is required to establish preferred preventive regimens for all paediatric DR-TB contacts.
    Abstract

    Keywords:
    Children,IGRA,Multidrug-resistant,TB-contact,Tuberculosis

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