Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dissociative Amnesia01:21

Dissociative Amnesia

Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Amnesia01:13

Amnesia

Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.

JAMA·2026
Same author

Alzheimer's disease.

Lancet (London, England)·2026
Same author

Retinal biomarkers for early Alzheimer's detection: a systematic review of optical coherence tomography (OCT) findings.

BMJ open ophthalmology·2026
Same author

Drug Development.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Alzheimer's Imaging Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative.

Alzheimer's research & therapy·2025

Related Experiment Video

Updated: May 7, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Two distinct amnesic profiles in behavioral variant frontotemporal dementia.

Maxime Bertoux1, Leonardo Cruz de Souza2, Fabian Corlier3

  • 1Brain & Spine Institute (ICM), INSERM UMRS 975, Paris; Université Pierre et Marie Curie, Sorbonne Universités, Paris; Alzheimer Institute, Department of Neurology, Hôpital Pitié-Salpêtrière (Assistance Publique - Hôpitaux de Paris), Paris; National Reference Centre for Rare Dementia, Hôpital Pitié-Salpêtrière (Assistance Publique - Hôpitaux de Paris), Paris.

Biological Psychiatry
|October 5, 2013
PubMed
Summary

Behavioral variant frontotemporal dementia (bvFTD) patients show two distinct episodic memory profiles, with half exhibiting severe deficits similar to Alzheimer's disease (AD) patients.

Keywords:
Alzheimer’s diseaseamnesiadiagnosisepisodic memoryfrontotemporal dementianeuropsychology

More Related Videos

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

Related Experiment Videos

Last Updated: May 7, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Dementia Research

Background:

  • Episodic memory deficits are critical for diagnosing behavioral variant frontotemporal dementia (bvFTD).
  • Distinguishing bvFTD from Alzheimer's disease (AD) is essential for accurate diagnosis and management.
  • Understanding memory profiles in bvFTD aids in refining diagnostic criteria.

Purpose of the Study:

  • To compare the episodic memory performance profile of bvFTD patients with healthy controls and AD patients.
  • To investigate whether episodic memory deficits are a characteristic feature of bvFTD.
  • To identify distinct memory profiles within the bvFTD cohort.

Main Methods:

  • Compared episodic memory using the Free and Cued Selective Reminding Test in 56 AD patients, 56 bvFTD patients, and 22 controls.
  • Utilized clinical and biological criteria (CSF biomarkers, PET imaging) for AD and bvFTD diagnosis.
  • Assessed encoding, consolidation, and storage aspects of episodic memory.

Main Results:

  • Episodic memory scores did not reliably differentiate bvFTD from AD patients (sensitivity/specificity <50%).
  • Half of bvFTD patients displayed severe deficits in free recall, total recall, and delayed recall, comparable to AD patients.
  • The other half of bvFTD patients showed subnormal scores similar to phenocopies, with delayed recall resembling controls.

Conclusions:

  • bvFTD patients exhibit two distinct amnesic profiles, suggesting varied hippocampal and Papez circuit involvement.
  • These memory profiles offer insights into the heterogeneity of bvFTD.
  • Findings may inform current international consensus criteria for bvFTD diagnosis.