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Related Experiment Video

Updated: May 7, 2026

Mouse Hindbrain Ex Vivo Culture to Study Facial Branchiomotor Neuron Migration

Mouse Hindbrain Ex Vivo Culture to Study Facial Branchiomotor Neuron Migration

Published on: March 18, 2014

Facial motor neuron migration advances.

Sarah J Wanner¹, Ivan Saeger, Sarah Guthrie

¹Department of Organismal Biology and Anatomy, The University of Chicago, 1027 E 57th Street, Chicago, IL 60637, United States.

Current Opinion in Neurobiology

|October 5, 2013

Summary

Facial branchiomotor (FBM) neuron migration is crucial for neural circuit formation. Planar cell polarity signaling guides this migration, with species-specific differences observed between mice and zebrafish.

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Area of Science:

Neuroscience
Developmental Biology
Cell Migration

Background:

Correct neural circuit formation relies on precise neuronal migration during development.
Facial branchiomotor (FBM) neurons migrate tangentially in the hindbrain of mice and zebrafish.

Purpose of the Study:

To investigate the conserved and divergent mechanisms of FBM neuron migration.
To understand the role of planar cell polarity signaling in FBM neuron migration.

Main Methods:

Genetic studies in zebrafish and mouse models.
High-resolution time-lapse imaging in zebrafish.

Main Results:

Planar cell polarity signaling is a critical, conserved factor in FBM neuron migration.
Zebrafish FBM neuron migration involves pioneer neurons and interactions with axon tracts and basement membranes.
Species-specific differences in FBM neuron migration mechanisms are evident.

Conclusions:

Planar cell polarity signaling is essential for FBM neuron migration across species.
Environmental cues and pioneer neurons play key roles in zebrafish FBM neuron migration.
Comparative studies reveal conserved and unique aspects of neuronal migration.