Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world outcomes of adjuvant therapies in stage III/IV melanoma: Insights from the French RIC-MEL cohort.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

The impact of the time-of-day in the administration of immunotherapy and its efficacy in patients with advanced melanoma: A retrospective observational study.

Annales de dermatologie et de venereologie·2025
Same author

Promoting clinical research in community-based practice: Threats and opportunities.

Annales de dermatologie et de venereologie·2024
Same author

Clinicopathological, dermoscopic features and circumstances of diagnosis of amelanotic or hypomelanotic melanoma: A prospective multicentric study in the French private medical sector.

Annales de dermatologie et de venereologie·2024
Same author

[Anterior orbital ischemia secondary to type 1 cryoglobulinemia: A case report and literature review].

La Revue de medecine interne·2024
Same author

Factors associated with early relapse of infantile haemangioma in children treated for at least six months with oral propranolol: A case-control study using the 2014-2021 French Ouest DataHub.

Annales de dermatologie et de venereologie·2023

Related Experiment Video

Updated: May 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

[Sclerodermatous changes in porphyria cutanea tarda: six cases].

R Khayat1, A Dupuy, I Pansé

  • 1Service de dermatologie, hôpital Saint-Louis, Assistance publique-Hôpitaux de Paris, 1, avenue Claude-Vellefaux, 75010 Paris, France.

Annales De Dermatologie Et De Venereologie
|October 5, 2013
PubMed
Summary

Sclerodermatous skin changes can be an early sign of porphyria cutanea tarda (PCT), even without typical blisters. Early diagnosis based on porphyrin levels is crucial for managing PCT and associated liver disease.

Keywords:
AlopeciaAlopécieMorpheaMorphéesPorphyria cutanea tardaPorphyrie cutanée tardiveSclerosisSclérodermieSyndrome sclérodermiformeUroporphyrinUroporphyrines

Related Experiment Videos

Last Updated: May 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Hepatology
  • Biochemistry

Background:

  • Porphyria cutanea tarda (PCT) typically presents with blistering, skin fragility, hypertrichosis, and hyperpigmentation on sun-exposed areas.
  • Sclerodermatous changes are less common manifestations of PCT, sometimes preceding or co-occurring with other symptoms.

Observation:

  • A retrospective study of six female patients (45-72 years) with sclerodermatous lesions on sun-exposed areas revealed PCT.
  • Four patients presented sclerodermatous changes mimicking morphea, one with diffuse sclerosis, and one with isolated sclerodermiform alopecia; five had malar hypertrichosis and three facial hyperpigmentation.
  • Histological findings were consistent with morphea or scleroderma, and all patients had abnormal liver tests, including cirrhosis in four cases. Excessive alcohol intake was noted in four patients.

Findings:

  • Sclerodermatous changes can be the initial cutaneous manifestation of PCT, preceding or occurring in the absence of classic symptoms like blisters or photosensitivity.
  • Abnormal liver tests, including cirrhosis, were common in patients with sclerodermatous PCT, suggesting a link between skin findings and underlying liver disease.
  • Elevated uroporphyrin levels confirmed PCT in all patients, and treatment (corticosteroids, phlebotomy, hydroxychloroquine) normalized porphyrin levels, leading to lesion improvement.

Implications:

  • Sclerodermatous changes on the neck, face, or neckline, especially with scarring alopecia and abnormal liver tests, should raise suspicion for PCT, even without typical blistering.
  • Diagnosis of PCT should be based on porphyrin levels rather than solely on skin biopsy for scleroderma, which can cause diagnostic delays.
  • Effective management of PCT through normalization of porphyrin levels can lead to the regression of sclerodermatous skin lesions and potentially improve associated liver conditions.