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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
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Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
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Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
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Related Experiment Video

Updated: May 7, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
11:44

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Hepatic changes in systemic infection.

Brijesh Srivastava1, Alexander Gimson

  • 1Department of Hepatology, Addenbrookes Hospital, Cambridge, UK.

Best Practice & Research. Clinical Gastroenterology
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

The liver

Keywords:
CholestasisExtra-hepatic infectionHepatic dysfunctionSepsis

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Last Updated: May 7, 2026

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
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"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Area of Science:

  • Immunology
  • Hepatology
  • Infectious Diseases

Background:

  • The liver plays a crucial role in host defense against systemic infections.
  • It modulates immunological responses and undergoes cellular/molecular changes during infection.
  • These changes involve pro-inflammatory cytokines impacting metabolic and immunological pathways.

Purpose of the Study:

  • To explore the molecular and immunological alterations in the liver during extra-hepatic systemic infections.
  • To understand the consequences of these changes on liver function.
  • To highlight the importance of immunological homeostasis in preventing hepatic dysfunction.

Main Methods:

  • Review of existing literature on liver immunology and systemic infections.
  • Analysis of cellular and molecular changes within the liver.
  • Examination of cytokine signaling pathways and their metabolic effects.

Main Results:

  • Systemic infections trigger pathogen-specific molecular and immunological changes in the liver.
  • These alterations are critical for the host's response to infection.
  • Imbalances in immunological homeostasis can lead to adverse liver outcomes and dysfunction.

Conclusions:

  • The liver's immune response to extra-hepatic infections involves complex molecular and cellular dynamics.
  • Understanding these changes is vital for managing hepatic complications during systemic infections.
  • Maintaining liver immunological homeostasis is key to preventing infection-induced liver injury.