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Related Concept Videos

Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

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Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
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Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

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Liver in haematological disorders.

Giulia Pieri1, Eleni Theocharidou, Andrew K Burroughs

  • 1The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, Royal Free Hampstead NHS Trust and Institute of Liver and Digestive Health, University College London, Pond Street, NW3 2QG London, United Kingdom.

Best Practice & Research. Clinical Gastroenterology
|October 5, 2013
PubMed
Summary

Hematological disorders, including myeloproliferative neoplasms, are frequently linked to liver conditions like Budd-Chiari syndrome and portal vein thrombosis (PVT). These blood disorders can worsen liver disease and impact treatment outcomes.

Keywords:
Budd–Chiari syndromeMyeloproliferative disordersPortal vein thrombosisPost-transplant lymphoproliferative disordersSinusoidal obstruction syndrome

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Area of Science:

  • Hematology
  • Hepatology
  • Oncology

Background:

  • Prothrombotic hematological disorders, especially myeloproliferative neoplasms, are prevalent in patients with Budd-Chiari syndrome and portal vein thrombosis (PVT).
  • Portal vein thrombosis (PVT) affects a quarter of cirrhosis patients, with increased incidence in advanced liver disease and hepatocellular carcinoma.
  • Intrahepatic microthrombosis may contribute to hepatic fibrosis, while sinusoidal obstruction syndrome is a complication of myeloablative treatment.

Purpose of the Study:

  • To highlight the significant association between prothrombotic hematological disorders and liver diseases such as Budd-Chiari syndrome and PVT.
  • To underscore the role of hematological conditions in the pathogenesis and complications of liver diseases.
  • To review liver involvement in primary hematological diseases and complications post-liver transplantation.

Main Methods:

  • Literature review and analysis of existing studies on hematological disorders and liver diseases.
  • Identification of common prothrombotic conditions associated with PVT and Budd-Chiari syndrome.
  • Examination of the impact of hematological disorders on liver disease progression and treatment.

Main Results:

  • A significant proportion of patients with Budd-Chiari syndrome and PVT have underlying prothrombotic hematological disorders.
  • PVT is common in cirrhosis, particularly with advanced disease and hepatocellular carcinoma, and can precipitate decompensation.
  • Hepatitis B reactivation and post-transplant lymphoproliferative disorders are significant concerns in patients with hematological malignancies and liver transplant recipients, respectively.

Conclusions:

  • Prothrombotic hematological disorders are a key factor in the development and progression of liver diseases like PVT and Budd-Chiari syndrome.
  • Early identification and management of hematological disorders are crucial for patients with liver conditions.
  • Liver involvement is common in primary hematological diseases, necessitating integrated care approaches.