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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction

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Diseases of the Liver and Gallbladder

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Inflammatory Bowel Disease I: Introduction01:26

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Related Experiment Video

Updated: May 7, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

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Published on: November 27, 2016

Liver abnormalities in bowel diseases.

Martin Kummen1, Erik Schrumpf, Kirsten Muri Boberg

  • 1Norwegian PSC Research Center, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Pb 4950 Nydalen, N-0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Best Practice & Research. Clinical Gastroenterology
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

Liver abnormalities frequently occur with bowel diseases like inflammatory bowel disease (IBD) and coeliac disease. Primary sclerosing cholangitis (PSC) is a common liver complication in IBD.

Keywords:
Biliary tract diseaseCeliac diseaseInflammatory bowel diseaseLiver diseasePrimary sclerosing cholangitis

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08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Area of Science:

  • Gastroenterology
  • Hepatology
  • Immunology

Background:

  • Liver abnormalities are common in patients with bowel diseases.
  • Distinguishing between separate conditions and causal relationships can be challenging.
  • Hepatic disorders are frequent extraintestinal manifestations of inflammatory bowel disease (IBD) and coeliac disease.

Purpose of the Study:

  • To review the spectrum of liver abnormalities associated with IBD and coeliac disease.
  • To highlight the common hepatic disorders, including primary sclerosing cholangitis (PSC) and primary biliary cirrhosis.
  • To discuss the current understanding of the molecular etiology and pathophysiology of these conditions.

Main Methods:

  • Literature review of studies on liver diseases in IBD and coeliac disease.
  • Analysis of genetic associations between IBD and PSC.
  • Summary of clinical observations regarding hepatic manifestations.

Main Results:

  • Primary sclerosing cholangitis (PSC) is the most frequent hepatic disorder in IBD.
  • Primary biliary cirrhosis is common in coeliac disease.
  • Other common liver issues in IBD include steatosis, cholelithiasis, and treatment-related hepatic injury.
  • Less common findings include liver abscesses, hepatic thromboembolic events, granulomatous liver disease, and hepatic amyloidosis.

Conclusions:

  • Hepatic disorders are significant extraintestinal manifestations of IBD and coeliac disease.
  • While genetic links between IBD and PSC are emerging, a complete understanding of their etiology is lacking.
  • Liver transplantation remains the only curative option for PSC; other liver conditions require specific management strategies.