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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction to Connective Tissues01:11

Introduction to Connective Tissues

Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts, osteocytes,...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

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Updated: May 7, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Liver abnormalities in connective tissue diseases.

Maria De Santis1, Chiara Crotti, Carlo Selmi

  • 1Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy; BIOMETRA Department, University of Milan, Milan, Italy.

Best Practice & Research. Clinical Gastroenterology
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

The liver plays a role in immunity but can be affected by autoimmune liver diseases (AILD) and connective tissue diseases (CTD). Early screening for viral hepatitis is crucial for managing liver conditions in CTD patients.

Keywords:
AILDASAutoimmune liver diseaseCTDDMNRHPMSLESScSystemic lupus erythematosusViral hepatitisanti-syntehase syndromeautoimmune liver diseaseconnective tissue diseasedermatomyositisnodular regenerative hyperplasiapSSpolymiositisprimary Sjogren syndromesystemic lupus erythematosussystemic sclerosis

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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
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Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Related Experiment Videos

Last Updated: May 7, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
11:44

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

Area of Science:

  • Hepatology
  • Immunology
  • Rheumatology

Background:

  • The liver is a lymphoid organ involved in immune responses and self-tolerance.
  • It is susceptible to autoimmune reactions, leading to primary liver autoimmune diseases (AILD).
  • The liver is also frequently affected by connective tissue diseases (CTD), presenting with biochemical abnormalities.

Purpose of the Study:

  • To provide a general overview of liver involvement in CTD.
  • To help rheumatologists differentiate common clinical scenarios of liver involvement in CTD.
  • To highlight the importance of screening for viral hepatitis and drug-induced liver injury.

Main Methods:

  • Review of existing literature on liver involvement in CTD.
  • Analysis of common liver manifestations in various CTDs.
  • Discussion of diagnostic and management considerations.

Main Results:

  • CTD commonly cause cholestatic or hepatocellular patterns in liver function tests.
  • Unusual liver conditions like nodular regenerative hyperplasia and Budd-Chiari syndrome are increasingly reported in CTD.
  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) reactivation, drug-induced liver injury, and concomitant AILD are key concerns.

Conclusions:

  • Liver involvement in CTD requires careful evaluation to distinguish from primary liver diseases.
  • Screening for HBV and HCV is essential to prevent reactivation and manage treatment effectively.
  • Understanding drug-induced liver injury and AILD is critical for optimal patient care in CTD.