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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
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Published on: September 11, 2019

Liver abnormalities in the immunosuppressed.

Michelle C M Cheung1, Kosh Agarwal

  • 1Institute of Liver Studies, King's College Hospital Foundation Trust, King's Health Partners, Denmark Hill, London SE5 9RS, United Kingdom.

Best Practice & Research. Clinical Gastroenterology
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

Immunosuppression from illness or drugs can cause liver problems. This review covers common immunosuppressed conditions and associated liver diseases, emphasizing viral hepatitis and HIV co-infection.

Keywords:
Coinfection/drug therapyGraft-versus-host diseaseHIV infections/drug therapyHIV infections/virologyHaematopoietic stem cell transplantationHepatitis B, chronic/drug therapyHepatitis B, chronic/epidemiologyHepatitis B, chronic/prevention & controlHepatitis C, chronic/drug therapyHepatitis C, chronic/epidemiologyImmunosuppressionInterferons/therapeutic useKidney diseases/virologyLiver/pathology

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Area of Science:

  • Hepatology
  • Immunology
  • Clinical Medicine

Background:

  • Immunosuppression, whether from medical conditions or therapies, frequently leads to various liver complications.
  • Viral hepatitis (Hepatitis B and C) is a significant concern in immunosuppressed patients undergoing chemotherapy, transplantation, or biological therapies for autoimmune disorders.

Purpose of the Study:

  • To discuss common immunosuppressed conditions and their associated liver diseases.
  • To highlight the spectrum of liver diseases in iatrogenic immunosuppression.
  • To provide learning and practice points for clinicians regarding liver derangements in immunosuppressed patients.

Main Methods:

  • Literature review of commonly encountered immunosuppressed conditions.
  • Discussion of specific liver diseases associated with these conditions.
  • Overview of viral hepatitis (B and C) and human immunodeficiency virus (HIV) co-infection.

Main Results:

  • Immunosuppression presents a diverse range of liver derangements.
  • Viral hepatitis (B and C) is prevalent in immunosuppressed patients, especially those on chemotherapy, transplant recipients, and those on biological therapies.
  • HIV co-infection with Hepatitis B and C is a relevant clinical consideration.

Conclusions:

  • Recognition and prevention of viral liver disease are critical in immunosuppressed patients.
  • Early expert consultation before initiating immunosuppressive therapy is advised to manage potential liver complications.
  • Clinicians should be aware of the varied liver diseases that can manifest in immunosuppressed states.