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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

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Related Experiment Video

Updated: May 7, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Marginal zone lymphomas and infectious agents.

Andrés J M Ferreri1, Silvia Govi, Maurilio Ponzoni

  • 1Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy; Division of Onco-Hematological Medicine, Department of Onco-Hematology, San Raffaele Scientific Institute, Milan, Italy.

Seminars in Cancer Biology
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

Infectious agents like bacteria and viruses are linked to marginal zone lymphomas. This review explores microbial associations, including Helicobacter pylori and hepatitis C virus, with these lymphomas.

Keywords:
BorreliaChlamydophila psittaciHelicobacter pyloriHepatitis C virusLymphomagenesisMALT-type lymphomaMarginal zone lymphomas

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Area of Science:

  • Oncology
  • Infectious Diseases
  • Microbiology

Background:

  • Infectious agents, particularly bacteria and viruses, are increasingly recognized as contributing factors in various lymphoma entities.
  • Marginal zone lymphomas (MZLs), encompassing extranodal, nodal, and splenic forms, exhibit frequent associations with chronic infections.
  • These associations have significant clinical, molecular, biological, and therapeutic implications.

Purpose of the Study:

  • To review the established and emerging links between microbial infections and marginal zone lymphomas.
  • To discuss the biological mechanisms, clinical presentations, and therapeutic strategies related to these lymphoma-microbial associations.
  • To highlight future research directions in understanding and managing these conditions.

Main Methods:

  • Literature review of studies investigating the association between infectious agents and marginal zone lymphomas.
  • Analysis of clinical, molecular, and biological data from relevant research.
  • Synthesis of information regarding therapeutic implications and future perspectives.

Main Results:

  • Established links include Helicobacter pylori with gastric MALT lymphoma, Chlamydophila psittaci with ocular adnexal MALT lymphoma, and Borrelia burgdorferi with cutaneous MALT lymphoma.
  • Hepatitis C virus is extensively studied in association with various marginal zone lymphomas.
  • These microbial associations influence the pathogenesis, clinical behavior, and treatment response of MZLs.

Conclusions:

  • Chronic infections play a significant role in the development and progression of marginal zone lymphomas.
  • Understanding these microbial associations is crucial for developing targeted therapies and improving patient outcomes.
  • Further research is warranted to elucidate the complex interplay between microbes and MZLs and to explore novel therapeutic interventions.