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Abdominal Regions and Quadrants

To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
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Gut-Brain Axis

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The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the brain can only use...
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Neural Regulation

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Related Experiment Video

Updated: May 7, 2026

Caudal-to-cranial Approach in Laparoscopic Right Hemicolectomy with Complete Mesocolon Excision and D3 Lymph Node Dissection
06:46

Caudal-to-cranial Approach in Laparoscopic Right Hemicolectomy with Complete Mesocolon Excision and D3 Lymph Node Dissection

Published on: January 9, 2026

Your gut is right to turn left.

Olga Klezovitch1, Valeri Vasioukhin

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Developmental Cell
|October 5, 2013
PubMed
Summary

The transcription factor Pitx2 regulates gut asymmetry. Researchers found that Pitx2 controls the formin Daam2, which is essential for gut development and left-right patterning.

Area of Science:

  • Developmental biology
  • Molecular genetics

Background:

  • Left-right asymmetry is crucial for organogenesis.
  • The transcription factor Pitx2 is a known regulator of embryonic asymmetry.
  • Wnt signaling pathways play a role in gut development.

Purpose of the Study:

  • To identify downstream targets of Pitx2 involved in asymmetric gut development.
  • To elucidate the molecular mechanisms by which Pitx2 controls gut morphogenesis.

Main Methods:

  • Gene expression analysis
  • Protein interaction studies
  • Morphogenetic assays in developing gut models

Main Results:

  • The formin Daam2 was identified as a direct transcriptional target of Pitx2.

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  • Daam2 acts as a cellular effector of Wnt signaling downstream of Pitx2.
  • Pitx2-mediated regulation of Daam2 is essential for establishing gut left-right asymmetry.
  • Conclusions:

    • Formin Daam2 is a key downstream effector of Pitx2 in regulating gut asymmetry.
    • This study reveals a novel mechanism linking Pitx2 to Wnt signaling and cytoskeletal dynamics for asymmetric organogenesis.