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Folate: metabolism, genes, polymorphisms and the associated diseases

Fakhira Hassan Nazki1, Aga Syed Sameer, Bashir Ahmad Ganaie

  • 1Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, Kashmir 190006, India.

Gene
|October 5, 2013
PubMed
Summary

Folate, essential for DNA synthesis and methylation, is crucial for health. Gene variations and diet impact folate metabolism, potentially leading to diseases like cancer and neural tube defects.

Keywords:
CBSCTHDHFDHFRDNA methyltransferasesDNMTsDSDown's syndromeFolateMTHFRMTRMTRRNTDPolymorphismsS-adenosylhomocysteineS-adenosylmethionineSAHSAMTHFTScystathionine β-synthasecystathionine γ-lyasedTMPdUMPdeoxythymidylate monophosphatedeoxyuridylate monophosphatedi-hydro folatedi-hydro folate reductasemethionine synthasemethylene tetra-hydro folate reductaseneural tube defectstetra-hydro folatethymidylate synthetase

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