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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

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Utilization management in toxicology.

Yan Zhang¹, Tai C Kwong

¹Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, United States.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|October 5, 2013

Summary

Clinical toxicology testing is crucial for emergency departments and pain management. Optimizing test utilization requires understanding methodologies, drug metabolism, and clear communication for effective patient care.

Keywords:

11-nor-9-carboxy(∆9)tetrahydrocannabinol 2-ethylidene-1,5-dimethyl-3-3-diphenylpyrrolidine 3,4-methylenedioxyamphetamine 3,4-methylenedioxymethamphetamine CLIA Clinical Laboratory Improvement Amendments ED EDDP EG Emergency department HCPCS HPLC Healthcare Common Procedure Coding System LC MDA MDMA MS POCT Pain management Reimbursement TAT THCCOOH Toxicology UDT Urine drug testing Utilization management emergency department ethylene glycol high pressure (performance) liquid chromatography liquid chromatography mass spectrometry point-of-care testing turnaround time urine drug testing

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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)

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Published on: May 10, 2016

Area of Science:

Clinical Chemistry
Toxicology
Laboratory Medicine

Background:

Rising prescription drug and illicit substance abuse necessitates enhanced toxicology testing.
Clinical laboratories face challenges in managing toxicology test utilization for emergency and pain management settings.

Purpose of the Study:

To review the challenges in clinical toxicology testing utilization.
To discuss strategies for optimal test selection and timely result delivery in emergency departments.
To examine the role of urine drug testing in chronic pain management and patient compliance.

Main Methods:

Review of current practices in clinical toxicology testing.
Discussion of tiered testing systems and turnaround time requirements.
Analysis of factors influencing test selection, including performance characteristics and reimbursement.

Main Results:

Optimal emergency department toxicology testing requires appropriate test selection and rapid results.
Urine drug testing is vital for monitoring compliance in chronic pain patients.
Understanding test performance, drug metabolism, and reimbursement is key for effective utilization.

Conclusions:

Effective toxicology test utilization hinges on analytical and clinical interpretation.
Collaboration and communication among healthcare professionals, patients, and lab professionals are essential.
Addressing challenges in toxicology testing supports better patient outcomes in emergency and pain management contexts.