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Updated: May 7, 2026
06:28
E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
Preparing the patient for success: treat or wait?
1Liver Unit, Hospital Universitario Vall d'Hebron, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
Summary
Predicting outcomes for chronic hepatitis C (HCV) patients is difficult. Antiviral therapy is recommended for all, but treatment timing depends on individual patient factors and disease progression risk.
Area of Science:
- Hepatology
- Infectious Diseases
- Oncology
Background:
- Hepatitis C virus (HCV) infection frequently leads to liver cirrhosis and hepatocellular carcinoma globally.
- Predicting clinical outcomes in chronic hepatitis C patients presents significant challenges due to non-linear disease progression.
- Current antiviral therapies achieve sustained virologic response in approximately 70% of treatment-naïve patients, regardless of HCV genotype.
Purpose of the Study:
- To outline the complexities in predicting clinical outcomes for patients with chronic hepatitis C.
- To emphasize that all patients with hepatitis C virus infection are candidates for antiviral therapy.
- To discuss the factors influencing the decision-making process for initiating antiviral treatment.
Main Methods:
- Review of the natural history of hepatitis C virus infection.
- Assessment of fibrosis staging in chronic hepatitis C.
- Evaluation of current antiviral therapy efficacy and adverse effect profiles.
Main Results:
- Sustained virologic response rates of around 70% are achievable with current therapies in treatment-naïve patients.
- Hepatitis C virus patients are generally considered candidates for antiviral treatment.
- Treatment decisions involve a complex interplay of disease factors and patient-specific considerations.
Conclusions:
- The decision to initiate antiviral therapy for chronic hepatitis C requires careful consideration of individual patient characteristics.
- Factors such as disease progression risk, patient preferences, and physician experience are crucial.
- Tailoring treatment strategies, including timing, is essential for optimal patient management in chronic hepatitis C.
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