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Variation in antibiotic susceptibility of uropathogens by age among ambulatory pediatric patients

Jessina C McGregor1, Yennie Quach1, David T Bearden1

  • 1Department of Pharmacy Practice, College of Pharmacy, Oregon State University/Oregon Health & Science University, Portland, OR.

Journal of Pediatric Nursing
|October 5, 2013
PubMed

Insights

Pediatric urinary tract infection antibiotic resistance varies by age. Young children under age 2 showed lower susceptibility to common antibiotics like trimethoprim/sulfamethoxazole and ampicillin compared to older children.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance
  • Urology

Background:

  • Antibiotic resistance in uropathogens poses a significant challenge in pediatric care.
  • Understanding age-related variations in susceptibility is crucial for effective treatment of urinary tract infections (UTIs).

Purpose of the Study:

  • To compare antibiotic susceptibility patterns of common uropathogens across different age groups in ambulatory pediatric patients.
  • To identify potential age-specific differences in resistance to frequently prescribed urinary anti-infectives.

Main Methods:

  • Retrospective analysis of uropathogen antibiotic susceptibility data from pediatric patients.
  • Comparison of susceptibility rates for Escherichia coli and other Gram-negative rods across defined age strata.
  • Statistical analysis (p<0.05) to determine significant differences in susceptibility.

Main Results:

  • Significant age-related differences (p<0.05) in susceptibility were observed for ampicillin, cefazolin, and trimethoprim/sulfamethoxazole.
  • Escherichia coli susceptibility to trimethoprim/sulfamethoxazole ranged from 79% (under 2 years) to 88% (16-18 years).
  • Ampicillin susceptibility in E. coli varied from 30% (under 2 years) to 53% (2-5 years).

Conclusions:

  • Uropathogen susceptibility to key urinary anti-infectives may be reduced in the youngest pediatric populations.
  • These findings highlight the need for further investigation into age-specific resistance patterns.
  • Guiding appropriate and judicious antibiotic selection for pediatric UTIs is essential.

Keywords:
Ambulatory careAntibiotic resistanceUrinary tract infection

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