Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Endocrine System01:29

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that every...
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
Structures of the Endocrine System00:59

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles.

Cell reports·2026
Same author

Opposing gastric and jejunal regulation of CELA2A in obesity and after Roux-en-Y gastric bypass suggests a role in gastrointestinal metabolic signaling.

Frontiers in endocrinology·2026
Same author

Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner.

Translational psychiatry·2026
Same author

The Role of Digital Tools and Their Implementation Within Patient Care Pathways for Rare Brain Disorders: The Case of Phenylketonuria.

European journal of neurology·2026
Same author

Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice.

Nature communications·2026
Same author

Nutritional psychiatry on the move: the activities of the ECNP Nutrition Network to leverage nutrition for brain health.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026

Related Experiment Video

Updated: May 7, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

Enteroendocrine hormones - central effects on behavior.

Karolina P Skibicka1, Suzanne L Dickson

  • 1Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden.

Current Opinion in Pharmacology
|October 5, 2013
PubMed
Summary

Gut hormones like ghrelin, GLP-1, and CCK influence brain functions including reward, mood, and memory. Their roles in feeding behavior and metabolic control are increasingly understood.

More Related Videos

Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings
09:39

Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings

Published on: March 17, 2023

Related Experiment Videos

Last Updated: May 7, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings
09:39

Hypothalamic Kisspeptin Neurons as a Target for Whole-Cell Patch-Clamp Recordings

Published on: March 17, 2023

Area of Science:

  • Neuroendocrinology
  • Behavioral Neuroscience
  • Metabolic Regulation

Background:

  • Appetite-regulating gut hormones significantly impact brain functions beyond feeding.
  • Hormonal signals, potentially originating in the central nervous system (CNS), modulate reward, anxiety, mood, memory, and cognition.
  • Nutritional status and bariatric surgery alter gut hormone secretion, suggesting a link to neurobiological effects and feeding control.

Purpose of the Study:

  • To explore the neurobiological roles of appetite-regulating gut hormones.
  • To understand how these hormones integrate with feeding and metabolic control.
  • To investigate the specific behavioral effects of key gut hormones like ghrelin, GLP-1, CCK, and PYY.

Main Methods:

  • Review of existing literature on gut hormones and their effects on behavior and cognition.
  • Analysis of physiological roles in feeding initiation and metabolic regulation.
  • Examination of behavioral changes associated with specific hormones in preclinical models.

Main Results:

  • Ghrelin enhances motivated feeding behavior and reduces anxiety-related behaviors when food is scarce.
  • Anorexigenic signals, including glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), are associated with reduced reward function.
  • Cholecystokinin (CCK) and potentially GLP-1 are linked to increased anxiety-like behaviors.

Conclusions:

  • Gut hormones play a crucial role in integrating feeding behavior with broader neurobiological functions, including reward and anxiety.
  • These hormones are key mediators between nutritional status, metabolic control, and central nervous system activity.
  • Further research into CNS-derived signals and specific hormone actions is warranted to fully elucidate their impact on behavior and cognition.