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Updated: May 7, 2026
09:52
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
[A case of cavernous sinus aspergillosis]
Tomomi Hase1, Hideharu Kurita, Eiji Matsumoto
1Department of Neurosurgery, International University of Health and Welfare Hospital.
No Shinkei Geka. Neurological Surgery
|October 5, 2013
Summary
Cavernous sinus aspergillosis, a rare fungal infection, can cause severe neurological symptoms. Early diagnosis and voriconazole treatment improved a patient
Area of Science:
- Neurology
- Infectious Diseases
- Ophthalmology
Background:
- Cavernous sinus aspergillosis is a rare but serious fungal infection.
- It often arises secondary to sphenoid sinusitis.
- Invasion of the internal carotid artery can lead to cerebral infarction and poor prognosis.
Observation:
- A 62-year-old male presented with trigeminal neuralgia, ptosis, and ophthalmoplegia externa.
- MRI revealed a cavernous sinus mass and sphenoid sinusitis; MRA showed internal carotid artery occlusion.
- Histopathology confirmed Aspergillus hyphae in the cavernous sinus.
Findings:
- Surgical biopsy via an extradural temporopolar approach facilitated diagnosis.
- Early treatment with voriconazole led to significant improvement in neurological deficits.
- The epidural approach helped prevent further fungal dissemination.
Implications:
- Aspergillosis should be considered in the differential diagnosis of cavernous sinus masses.
- Prompt diagnosis and treatment are crucial for improving patient outcomes.
- Multidisciplinary management involving neurology, infectious disease, and surgery is essential.
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