Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulation of lymphocyte function by sensory neuropeptides.

D G Payan, E J Goetzl

    Journal of Immunology (Baltimore, Md. : 1950)
    |August 1, 1985
    PubMed
    Summary

    Neuropeptides from the nervous system influence immune cells like lymphocytes and macrophages. These interactions, mediated by receptors, impact immunity and hypersensitivity responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lenalidomide enhancement of human T cell functions in human immunodeficiency virus (HIV)-infected and HIV-negative CD4 T lymphocytopenic patients.

    Clinical and experimental immunology·2012
    Same author

    Approaches to discovering drugs that regulate E3 ubiquitin ligases.

    Ernst Schering Foundation symposium proceedings·2009
    Same author

    Stable, stoichiometric delivery of diverse protein functions.

    Journal of biochemical and biophysical methods·2004
    Same author

    First international conference on lysophospholipids and related bioactive lipids in biology and disease sponsored by the Federation of American Societies of Experimental Biology.

    TheScientificWorldJournal·2003
    Same author

    Utility of peptide-protein affinity complexes in proteomics: identification of interaction partners of a tumor suppressor peptide.

    The journal of peptide research : official journal of the American Peptide Society·2003
    Same author

    The use of retroviruses as pharmaceutical tools for target discovery and validation in the field of functional genomics.

    Current opinion in biotechnology·2002

    Area of Science:

    • Neuroimmunology
    • Cellular immunology

    Background:

    • Neuropeptides are found in the peripheral nervous system (PNS) and central nervous system (CNS).
    • These neuropeptides modulate mononuclear leukocyte functions in various species.
    • Receptor-mediated mechanisms are involved in these modulatory effects.

    Purpose of the Study:

    • To investigate the role of neuropeptides in modulating immune cell functions.
    • To explore the impact of neuropeptides on lymphocytes and macrophages.
    • To understand how the nervous system influences immune responses.

    Main Methods:

    • In vitro and in vivo studies using human, murine, and guinea pig models.
    • Analysis of neuropeptide-leukocyte interactions via receptor binding.
    • Assessment of stimulatory and inhibitory effects on immune cells.

    Main Results:

    • Neuropeptides exhibit both stimulatory and inhibitory effects on lymphocytes and macrophages.
    • Observed effects occur at physiological concentrations found in circulation and tissues.
    • Neuropeptide-receptor binding affinities (KD) correlate with immune response concentrations.

    Conclusions:

    • Neuropeptides significantly influence mononuclear leukocyte functions through receptor-mediated pathways.
    • The PNS and CNS can modulate localized and systemic immunity, respectively, via neuropeptide signaling.
    • These findings highlight a crucial link between the nervous and immune systems.

    Related Experiment Videos