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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Pulmonary Edema II: Pathophysiology01:18

Pulmonary Edema II: Pathophysiology

Pulmonary edema is the accumulation of fluid in the interstitial and alveolar spaces of the lungs, impairing gas exchange and oxygen delivery. It may be cardiogenic or noncardiogenic, but both reduce oxygenation and lung compliance.Cardiogenic Pulmonary EdemaCardiogenic edema results from increased hydrostatic pressure in pulmonary capillaries, usually due to left ventricular dysfunction from myocardial infarction, heart failure, or valvular disease. Ineffective cardiac pumping causes blood to...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...

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Related Experiment Video

Updated: May 7, 2026

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
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Pulmonary hypertension: pathology.

Peter Dorfmüller1

  • 1Service d'Anatomie et de Cytologie Pathologiques, Hôpital Marie Lannelongue, 133, Avenue de la Résistance, Le Plessis Robinson, France, peter.dorfmuller@u-psud.fr.

Handbook of Experimental Pharmacology
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

Pulmonary hypertension (PH) is a severe condition. Lung histology offers insights into PH causes and disease progression, aiding pathological understanding.

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Area of Science:

  • Pathology
  • Cardiovascular Medicine
  • Pulmonology

Background:

  • Pulmonary hypertension (PH) is a critical illness with high mortality.
  • It involves elevated pulmonary vascular resistance and right ventricular failure.
  • PH has diverse etiologies and complex pathogenesis.

Purpose of the Study:

  • To explore the role of lung histology in understanding PH.
  • To correlate histological findings with etiological factors and disease mechanisms.
  • To present the current understanding of PH from a pathologist's perspective.

Main Methods:

  • Histological examination of lung tissue from PH patients.
  • Analysis of cellular and structural involvement in lung pathology.
  • Correlation of morphological features with disease characteristics.

Main Results:

  • Lung histology reveals varying degrees of cell and structure involvement in PH.
  • Morphological patterns can indicate specific etiological factors.
  • Histopathology provides crucial insights into the pathophysiological processes of PH.

Conclusions:

  • While pathologists have a limited role in routine PH management, morphological analysis is valuable.
  • Histology aids in identifying etiological factors and understanding disease complexity.
  • Pathological insights contribute to a comprehensive understanding of pulmonary hypertension.