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Related Experiment Video

Updated: May 7, 2026

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds

Published on: June 6, 2015

Chick heart invasion assay.

Marc E Bracke¹, Virinder S Parmar, Anthony L Depass

¹Department of Radiotherapy and Nuclear Medicine, Laboratory of Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.

Methods in Molecular Biology (Clifton, N.J.)

|October 5, 2013

Summary

Tumor microenvironments involve complex interactions between cancer and host cells. Organ culture models, using embryonic chick heart fragments, allow studying these cancer cell-host tissue interactions and their impact on tumor invasion.

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Last Updated: May 7, 2026

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds

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Published on: March 17, 2020

Area of Science:

Oncology
Developmental Biology
Cell Biology

Background:

Tumors function as microecosystems with constant communication between cancer and host cells, influencing tumor invasion.
This cellular crosstalk involves secreted factors that modulate cell-ECM interactions, adhesion, ECM remodeling, and motility.

Purpose of the Study:

To investigate cancer cell-host tissue interactions within an organ culture system.
To utilize embryonic chick heart fragments as a model for studying tumor invasion dynamics.

Main Methods:

Employing organ culture techniques to confront cancer cells with living normal host tissue.
Utilizing embryonic chick heart fragments, which retain histological and functional integrity (contractility) during culture.

Main Results:

Embryonic chick heart fragments maintain histological features, including myocytes, fibroblasts, and endothelial cells.
The extracellular matrix (ECM) of the fragments contains key components like fibronectin, laminin, and collagens.
The contractile activity of the heart fragments serves as a reliable indicator of their functional integrity throughout the organ culture process.

Conclusions:

Organ culture systems provide a viable platform for studying the complex interactions within tumor microenvironments.
Embryonic chick heart fragments are a suitable model for investigating cancer cell invasion and host tissue responses.