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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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Correction to: Life-Threatening Infections Due to Live-Attenuated Vaccines: Early Manifestations of Inborn Errors of Immunity.

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Published on: December 31, 2007

Immunology taught by human genetics.

Jean-Laurent Casanova1, Laurent Abel2, Lluis Quintana-Murci3

  • 1St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York 10065 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U980, Necker Hospital for Sick Children, Paris 75015, France Paris Descartes University, Imagine Institute, Necker Hospital, Paris 75015, France casanova@rockefeller.edu.

Cold Spring Harbor Symposia on Quantitative Biology
|October 5, 2013
PubMed
Summary

Human genetics research offers new insights into immunity, revealing general principles of immune function and evolution. Studies in clinical, epidemiological, and evolutionary genetics illuminate how human immunity adapts to changing environments and medical interventions.

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Area of Science:

  • Human Molecular Genetics
  • Immunology
  • Evolutionary Biology

Background:

  • Human genetic studies traditionally focus on medical and evolutionary goals, not immunology.
  • Despite this, these studies have yielded significant immunological insights.
  • Human genetics offers a unique lens to study immunity under natural conditions.

Purpose of the Study:

  • To review immunological lessons from clinical, epidemiological, and evolutionary genetics.
  • To highlight human genetics as a frontier for understanding immunity.
  • To explore how environmental and medical changes impact immune genetics.

Main Methods:

  • Review of immunological findings from human genetic studies.
  • Analysis of clinical genetics in childhood phenotypes.
  • Examination of epidemiological and evolutionary genetics in population studies.

Main Results:

  • Human genetics reveals general principles of immunity and its evolution.
  • Modern medicine's impact on genomic diversity allows unbiased evolutionary studies.
  • Increased life expectancy enables study of genetic basis for non-counterselected immune phenomena like autoimmunity.

Conclusions:

  • Human genetics is crucial for understanding specific and general principles of immunity.
  • The transition from natural to medically shaped environments provides unique study opportunities.
  • Advanced technologies like deep sequencing and stem cells offer new avenues for immunological research in human genetics.