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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: May 7, 2026

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Inflammation, obesity, and thrombosis.

Fahumiya Samad1, Wolfram Ruf

  • 1Department of Cell Biology, Torrey Pines Institute for Molecular Studies, San Diego, CA; and.

Blood
|October 5, 2013
PubMed
Summary

Obesity is linked to thrombosis and metabolic syndrome via tissue factor (TF) signaling. Targeting TF pathways may offer new treatments for obesity, inflammation, and clotting disorders.

Area of Science:

  • Biomedical research
  • Molecular biology
  • Cardiovascular science

Background:

  • Obesity is associated with thrombosis, characterized by increased plasminogen activator inhibitor-1 and tissue factor (TF) expression, and heightened platelet activation.
  • Metabolic syndrome and related disorders involve inflammation driven by immune cell infiltration, particularly macrophages, in adipose tissue.
  • Tissue factor (TF) is implicated in obesity-related procoagulant states and metabolic dysfunction.

Purpose of the Study:

  • To explore the role of TF signaling pathways (TF-PAR2, TF-PAR1) in obesity and metabolic syndrome.
  • To investigate how TF-mediated signaling contributes to inflammation, insulin resistance, and hepatic steatosis.
  • To identify TF signaling as a potential therapeutic target for metabolic and thrombotic complications.

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Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
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Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

Related Experiment Videos

Last Updated: May 7, 2026

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

Main Methods:

  • Review of clinical and epidemiological studies.
  • Analysis of genetic and pharmacologic evidence.
  • Examination of TF signaling mechanisms in adipocytes and immune cells.

Main Results:

  • TF-PAR2 signaling in adipocytes reduces metabolism and energy expenditure, promoting diet-induced obesity.
  • TF-PAR2 signaling in myeloid cells drives adipose tissue inflammation, hepatic steatosis, and insulin resistance.
  • TF-initiated coagulation via thrombin-PAR1 signaling contributes to hepatic steatosis and inflammation in certain models.

Conclusions:

  • Prothrombotic markers in obese patients may predict metabolic syndrome complications.
  • TF-induced signaling presents potential therapeutic targets at the nexus of obesity, inflammation, and thrombosis.
  • Targeting TF pathways could offer novel strategies for managing obesity-related metabolic and cardiovascular risks.