Evolution and Conservation of Plant NLR Functions
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Updated: May 7, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
Florence Jacob1, Saskia Vernaldi, Takaki Maekawa
1Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research , Cologne , Germany ; Unité de Recherche en Génomique Végétale, Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, Université Evry Val d'Essone , Evry , France.
Abstract:
In plants and animals, nucleotide-binding domain and leucine-rich repeats (NLR)-containing proteins play pivotal roles in innate immunity. Despite their similar biological functions and protein architecture, comparative genome-wide analyses of NLRs and genes encoding NLR-like proteins suggest that plant and animal NLRs have independently arisen in evolution. Furthermore, the demonstration of interfamily transfer of plant NLR functions from their original species to phylogenetically distant species implies evolutionary conservation of the underlying immune principle across plant taxonomy. In this review we discuss plant NLR evolution and summarize recent insights into plant NLR-signaling mechanisms, which might constitute evolutionarily conserved NLR-mediated immune mechanisms.
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