Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

Overview
Pedigree Analysis01:35

Pedigree Analysis

Overview
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heritability of Alzheimer's disease-related plasma biomarkers in the Amish population.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

WDR12 and HIVEP3 are contributors to cognitive preservation in Amish SuperAgers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort study.

medRxiv : the preprint server for health sciences·2026
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: May 7, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

PedWiz: a web-based tool for pedigree informatics.

Yeunjoo E Song1, Robert C Elston

  • 1Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA.

Frontiers in Genetics
|October 5, 2013
PubMed
Summary
This summary is machine-generated.

PedWiz is a new web tool simplifying pedigree data analysis for researchers. It offers comprehensive informatics, including statistics and genetic sharing visualizations, aiding family-based studies.

Keywords:
family datagenetic similarityidentity-by-descentinformaticspedigreerelative pairs

More Related Videos

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Related Experiment Videos

Last Updated: May 7, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Area of Science:

  • Genetics
  • Bioinformatics
  • Computational Biology

Background:

  • Pedigree data is crucial for family-based genetic studies.
  • Analyzing complex family structures and genetic relationships can be challenging.
  • Existing tools may lack comprehensive informatics pipelines for pedigree data.

Purpose of the Study:

  • Introduce PedWiz, a novel web-based tool for pedigree data informatics.
  • To provide researchers with a convenient platform for analyzing family data.
  • To support genetic research utilizing linkage and other family-based methods.

Main Methods:

  • Developed a web-based tool, PedWiz, to automate pedigree data processing.
  • Integrated functionalities for descriptive statistics, relative pair analysis, and genetic similarity.
  • Included calculations for allele sharing, variance-covariance matrices, and identity coefficients.

Main Results:

  • PedWiz offers a streamlined informatics pipeline for pedigree data.
  • The tool provides descriptive statistics, genetic similarity coefficients, and identity visualizations.
  • It generates variance-covariance matrices for allele sharing and mean allele sharing.

Conclusions:

  • PedWiz is a valuable and convenient tool for researchers analyzing pedigree data.
  • The tool facilitates the analysis of family structures and genetic relationships.
  • It supports the growing interest in family-based genetic studies and methods.