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[Current perspectives in the management of non-small cell lung cancer]

J Fujita, N Saijo

    Gan No Rinsho. Japan Journal of Cancer Clinics
    |April 1, 1985
    PubMed

    Insights

    Combination chemotherapy shows promise for non-small cell lung cancer (NSCLC) treatment. Recent trials with drug combinations like VDS and CDDP achieve response rates of 40-50%, offering new hope for NSCLC patients.

    Area of Science:

    • Oncology
    • Pharmacology

    Context:

    • Chemotherapy for non-small cell lung cancer (NSCLC) has historically shown limited clinical benefit.
    • Recent advancements focus on combination chemotherapy to improve treatment efficacy.

    Purpose:

    • To review updated treatment schedules for combination chemotherapy in NSCLC.
    • To highlight progress in developing non-overlapping toxic antineoplastic drug combinations.

    Summary:

    • Clinical trials of combination chemotherapy using agents like vindesine (VDS) and cisplatin (CDDP) in NSCLC have demonstrated consistent response rates of approximately 40-50%.
    • This approach leverages multiple active antineoplastic agents with minimal overlapping toxicity.

    Impact:

    • Offers improved therapeutic options for NSCLC patients.
    • Provides a basis for further research into optimized combination chemotherapy regimens for lung cancer treatment.

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