Related Experiment Video
Updated: May 7, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Emerging therapies for soft-tissue sarcomas
Alice Levard1, Louis Tassy, Philippe A Cassier
1Department of Medical Oncology, Léon Bérard Cancer Center, 28 rue Laennec, Lyon 69008, France.
Abstract:
Sarcomas are heterogeneous group of tumors that arise from tissues of mesenchymal origin. Current options for patients with advanced disease are limited, and only 2 drugs have been approved for these diseases over the last decade. Although several drugs are currently under development for soft-tissue sarcoma as a whole, improved understanding of sarcoma biology has led to the emergence of subtype-specific targeted therapy. This article reviews recent clinical data on emerging therapies for soft-tissue sarcoma.
Insights
Advanced sarcoma treatment options are limited. Emerging subtype-specific targeted therapies show promise for soft-tissue sarcoma patients, offering new hope beyond current limited drug approvals.
Area of Science:
- Oncology
- Medical Research
Background:
- Sarcomas are rare cancers originating from mesenchymal tissues.
- Current treatments for advanced sarcomas are limited, with few drug approvals in the past decade.
Purpose of the Study:
- To review recent clinical data on emerging therapies for soft-tissue sarcoma.
- To highlight the shift towards subtype-specific targeted treatments.
Main Methods:
- Review of recent clinical trial data.
- Analysis of emerging therapeutic strategies in soft-tissue sarcoma.
Main Results:
- Several targeted therapies are under development for soft-tissue sarcoma.
- Emerging treatments are increasingly tailored to specific sarcoma subtypes.
Conclusions:
- Subtype-specific targeted therapy represents a significant advancement in sarcoma treatment.
- New therapeutic approaches are crucial for improving outcomes in advanced soft-tissue sarcoma.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy
Treatment Resistant Cancers

