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Related Experiment Video

Updated: May 7, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

The red ear syndrome.

Giorgio Lambru¹, Sarah Miller, Manjit S Matharu

¹Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. m.matharu@uclmail.net.

The Journal of Headache and Pain

|October 8, 2013

Summary

This summary is machine-generated.

Red Ear Syndrome (RES) is a rare disorder causing episodes of burning and redness in the ear. While often refractory to treatment, some migraine therapies may offer benefits for related cases.

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Area of Science:

Neurology
Otolaryngology

Background:

Red Ear Syndrome (RES) is an exceptionally rare condition, with limited published cases.
It presents as unilateral or bilateral episodes of burning sensations and erythema of the external ear.
Episodes vary in duration from seconds to hours and frequency from daily to yearly.

Purpose of the Study:

To summarize the characteristics, triggers, associations, and current treatment understanding of Red Ear Syndrome.
To explore potential pathophysiological mechanisms and clinical associations of RES.

Main Methods:

Literature review of published cases and case series on Red Ear Syndrome.
Analysis of reported clinical features, triggers, and treatment responses.
Review of proposed etiological hypotheses and associated conditions.

Main Results:

RES episodes can be spontaneous or triggered by stimuli like touch, temperature, chewing, or exertion.
Idiopathic RES is associated with migraine (early-onset) or trigeminal autonomic cephalalgias (late-onset).
Secondary RES is linked to cervical spine disorders or temporomandibular joint dysfunction.

Conclusions:

Red Ear Syndrome is challenging to treat, with limited efficacy of current medical interventions.
Migraine prophylactic treatments may provide some benefit, particularly in migraine-associated RES.
The underlying pathophysiology of RES remains largely unknown, with proposed nervous system mechanisms.