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Related Concept Videos

Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Related Experiment Video

Updated: May 7, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms

Published on: May 9, 2017

afterParty: turning raw transcriptomes into permanent resources.

Martin Jones1, Mark Blaxter

  • 1Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK. martin.jones@ed.ac.uk.

BMC Bioinformatics
|October 8, 2013
PubMed
Summary
This summary is machine-generated.

The afterParty web application simplifies the assembly, annotation, and publication of novel transcriptome data. This tool makes complex bioinformatics accessible to biologists, promoting data sharing and reusability.

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Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
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Published on: December 22, 2014

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Last Updated: May 7, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved (Non-model) Organisms
10:41

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Published on: May 9, 2017

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
11:23

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples

Published on: December 22, 2014

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Next-generation sequencing enables rapid transcriptome data generation for novel organisms.
  • Transcriptome annotation and publication efforts often exceed sequencing efforts.
  • Limited accessibility of annotation details hinders data exploitation.

Purpose of the Study:

  • To develop a web application, afterParty, for easy transcriptome assembly, annotation, and publication.
  • To promote best-practice in transcriptome annotation and data accessibility.
  • To reduce the bioinformatics expertise and computational resources required for transcriptome analysis.

Main Methods:

  • afterParty is a web application for assembling, annotating, browsing, searching, and visualizing transcriptomes.
  • It accepts raw reads or assembled contigs from various sequencing chemistries.
  • Functional annotation is based on sequence similarity and protein domain analysis.

Main Results:

  • afterParty transforms sequence data into searchable, browsable transcriptome resources.
  • Publicly accessible datasets can be generated quickly via the web server or local installations.
  • Comparative analysis and searching across multiple transcriptomes are supported.

Conclusions:

  • afterParty empowers biologists to create durable, useful transcriptome resources from raw sequence data.
  • It significantly lowers the barrier to annotating and sharing valuable transcriptome data.
  • A metazoan transcriptome with tens of thousands of contigs can be annotated efficiently.